Recombinant Protein rP21 from Trypanosoma cruzi has Effect on Inflammation, Angiogenesis and Fibrogenesis in Skin Wound Model C57BL/6 Mouse

Aims: Recombinant proteins rP2 has demonstrated biological activity in inflammation by acting on the recruitment of leukocytes and inducing phagocytosis, also modulating processes angiogenesis fibrogenesis different experimental models. In this study we evaluated effects recombinant protein rP21 from Trypanosama cruzi cutaneous wounds.
 Study Design: The wounds were induced back mice treated with at 1 µg/mL 50 concentration, for 3 7 days.
 Location Duration: Institute Biomedical Sciences Animal Breeding Network Rodents Federal University Uberlândia, between February 2015 2016.
 Methodology: contraction time wound, inflammatory cell activities (neutrophils macrophages), local collagen density evaluated.
 Sample: Wound induction was performed 64 male BALB / c approximately 9 weeks old.
 Results: Wounds showed less closure time, addition to exhibiting greater neutrophil initial phasis, which reduced simultaneously increased macrophage activity. pro-angiogenic pro-fibrogenic model.
 Conclusion: These results demonstrate first potential accelerating skin tissue repair.